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Epigenetic regulation of spinal cord gene expression controls Opioid-Induced Hyperalgesia

BACKGROUND: The long term use of opioids for the treatment of pain leads to a group of maladaptations which includes opioid-induced hyperalgesia (OIH). OIH typically resolves within few days after cessation of morphine treatment in mice but is prolonged for weeks if histone deacetylase (HDAC) activi...

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Detalhes bibliográficos
Main Authors: Liang, De-Yong, Sun, Yuan, Shi, Xiao-You, Sahbaie, Peyman, Clark, J David
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171542/
https://ncbi.nlm.nih.gov/pubmed/25217253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-10-59
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