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Epigenetic Regulation of Opioid-Induced Hyperalgesia, Dependence and Tolerance in Mice

Repeated administration of opioids such as morphine induces persistent behavioral changes including opioid-induced hyperalgesia (OIH), tolerance and physical dependence. In the current work we explored how the balance of histone acetyltransferase (HAT) vs. histone deacetylase (HDAC) might regulate t...

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Detalles Bibliográficos
Main Authors: Liang, De-Yong, Li, XiangQi, Clark, J David
Formato: Artigo
Idioma:Inglês
Publicado: 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539745/
https://ncbi.nlm.nih.gov/pubmed/23273833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2012.10.005
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