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Validation of the Multiple Sensor Mechanism of the Keap1-Nrf2 System

The Keap1-Nrf2 system plays a critical role in cellular defense against electrophiles and reactive oxygen species. Keap1 possesses a number of cysteine residues, some of which are highly reactive and serves as sensors for these insults. Indeed, point mutation of Cys151 abrogates the response to cert...

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Autori principali: Takaya, Kai, Suzuki, Takafumi, Motohashi, Hozumi, Onodera, Ko, Satomi, Susumu, Kensler, Thomas W, Yamamoto, Masayuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3539416/
https://ncbi.nlm.nih.gov/pubmed/22732183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.06.023
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