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Pharmacokinetics and brain penetration of LF-3-88, (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl]ethanol, a selective α4β2-nAChR partial agonist and promising antidepressant
LF-3-88 (2-[5-[5-(2(S)-azetidinylmethoxyl)-3-pyridyl]-3-isoxazolyl] ethanol) was identified as a highly selective α4β2-nAChRs partial agonist, with a K(i) value of 0.4 nM and EC(50) value of 110 nM. A sensitive and selective ultra high pressure liquid chromatography-tandem mass spectrometry (UHPLC-M...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3538945/ https://ncbi.nlm.nih.gov/pubmed/23246847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jchromb.2012.11.011 |
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