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Nitric oxide synthases activation and inhibition by metallacarborane cluster-based isoform-specific affectors

A small library of boron cluster and metallacarborane cluster-based ligands was designed, prepared and tested for isoform-selective activation or inhibition of the three nitric oxide synthase isoforms. Based on the concept of creating a hydrophobic analog of a natural substrate, a stable and non-tox...

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Main Authors: Kaplánek, Robert, Martásek, Pavel, Grüner, Bohumír, Panda, Satya, Rak, Jakub, Masters, Bettie Sue Siler, Král, Vladimír, Roman, Linda J.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538847/
https://ncbi.nlm.nih.gov/pubmed/23075390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300805x
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