Endotoxin- and ATP-neutralizing activity of alkaline phosphatase as a strategy to limit neuroinflammation

BACKGROUND: Alkaline phosphatase (AP) is a ubiquitously expressed enzyme which can neutralize endotoxin as well as adenosine triphosphate (ATP), an endogenous danger signal released during brain injury. In this study we assessed a potential therapeutic role for AP in inhibiting neuroinflammation usi...

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Main Authors: Huizinga, Ruth, Kreft, Karim L, Onderwater, Sabina, Boonstra, Joke G, Brands, Ruud, Hintzen, Rogier Q, Laman, Jon D
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538711/
https://ncbi.nlm.nih.gov/pubmed/23231745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-266
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