The Mincle-Activating Adjuvant TDB Induces MyD88-Dependent Th1 and Th17 Responses through IL-1R Signaling

Successful vaccination against intracellular pathogens requires the generation of cellular immune responses. Trehalose-6,6-dibehenate (TDB), the synthetic analog of the mycobacterial cord factor trehalose-6,6-dimycolate (TDM), is a potent adjuvant inducing strong Th1 and Th17 immune responses. We pr...

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Detalhes bibliográficos
Main Authors: Desel, Christiane, Werninghaus, Kerstin, Ritter, Manuel, Jozefowski, Katrin, Wenzel, Jens, Russkamp, Norman, Schleicher, Ulrike, Christensen, Dennis, Wirtz, Stefan, Kirschning, Carsten, Agger, Else Marie, da Costa, Clarissa Prazeres, Lang, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538599/
https://ncbi.nlm.nih.gov/pubmed/23308247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053531
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