Development and experimental test of support vector machines virtual screening method for searching Src inhibitors from large compound libraries

BACKGROUND: Src plays various roles in tumour progression, invasion, metastasis, angiogenesis and survival. It is one of the multiple targets of multi-target kinase inhibitors in clinical uses and trials for the treatment of leukemia and other cancers. These successes and appearances of drug resista...

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Hlavní autoři: Han, Bucong, Ma, Xiaohua, Zhao, Ruiying, Zhang, Jingxian, Wei, Xiaona, Liu, Xianghui, Liu, Xin, Zhang, Cunlong, Tan, Chunyan, Jiang, Yuyang, Chen, Yuzong
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538513/
https://ncbi.nlm.nih.gov/pubmed/23173901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-153X-6-139
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