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A Two-Step Target Binding and Selectivity Support Vector Machines Approach for Virtual Screening of Dopamine Receptor Subtype-Selective Ligands

Target selective drugs, such as dopamine receptor (DR) subtype selective ligands, are developed for enhanced therapeutics and reduced side effects. In silico methods have been explored for searching DR selective ligands, but encountered difficulties associated with high subtype similarity and ligand...

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Bibliografische gegevens
Hoofdauteurs: Zhang, Jingxian, Han, Bucong, Wei, Xiaona, Tan, Chunyan, Chen, Yuzong, Jiang, Yuyang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376116/
https://ncbi.nlm.nih.gov/pubmed/22720033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039076
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