A Two-Step Target Binding and Selectivity Support Vector Machines Approach for Virtual Screening of Dopamine Receptor Subtype-Selective Ligands

Target selective drugs, such as dopamine receptor (DR) subtype selective ligands, are developed for enhanced therapeutics and reduced side effects. In silico methods have been explored for searching DR selective ligands, but encountered difficulties associated with high subtype similarity and ligand...

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Bibliographic Details
Main Authors:	Zhang, Jingxian, Han, Bucong, Wei, Xiaona, Tan, Chunyan, Chen, Yuzong, Jiang, Yuyang
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science 2012
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3376116/ https://ncbi.nlm.nih.gov/pubmed/22720033 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039076
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A Two-Step Target Binding and Selectivity Support Vector Machines Approach for Virtual Screening of Dopamine Receptor Subtype-Selective Ligands

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