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Minicircle DNA Vectors Achieve Sustained Expression Reflected by Active Chromatin and Transcriptional Level
Current efforts in nonviral gene therapy are plagued by a pervasive difficulty in sustaining therapeutic levels of delivered transgenes. Minicircles (plasmid derivatives with the same expression cassette but lacking a bacterial backbone) show sustained expression and hold promise for therapeutic use...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3538319/ https://ncbi.nlm.nih.gov/pubmed/23183534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.244 |
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