Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding

The HIV-1 envelope glycoprotein (Env) undergoes conformational transitions consequent to CD4 binding and coreceptor engagement during viral entry. The physical steps in this process are becoming defined, but less is known about their significance as targets of antibodies potentially protective again...

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Detalhes bibliográficos
Main Authors: Guan, Yongjun, Pazgier, Marzena, Sajadi, Mohammad M., Kamin-Lewis, Roberta, Al-Darmarki, Salma, Flinko, Robin, Lovo, Elena, Wu, Xueji, Robinson, James E., Seaman, Michael S., Fouts, Timothy R., Gallo, Robert C., DeVico, Anthony L., Lewis, George K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538257/
https://ncbi.nlm.nih.gov/pubmed/23237851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217609110
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