Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding

The HIV-1 envelope glycoprotein (Env) undergoes conformational transitions consequent to CD4 binding and coreceptor engagement during viral entry. The physical steps in this process are becoming defined, but less is known about their significance as targets of antibodies potentially protective again...

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Main Authors: Guan, Yongjun, Pazgier, Marzena, Sajadi, Mohammad M., Kamin-Lewis, Roberta, Al-Darmarki, Salma, Flinko, Robin, Lovo, Elena, Wu, Xueji, Robinson, James E., Seaman, Michael S., Fouts, Timothy R., Gallo, Robert C., DeVico, Anthony L., Lewis, George K.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2013
主題:
PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538257/
https://ncbi.nlm.nih.gov/pubmed/23237851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217609110
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