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Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration
Urate is the end product of purine metabolism in humans, owing to the evolutionary disruption of the gene encoding urate oxidase (UOx). Elevated urate can cause gout and urolithiasis and is associated with cardiovascular and other diseases. However, urate also possesses antioxidant and neuroprotecti...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3538212/ https://ncbi.nlm.nih.gov/pubmed/23248282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217296110 |
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