Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice

Disrupted brain iron homeostasis is a common feature of neurodegenerative disease. To begin to understand how neuronal iron handling might be involved, we focused on dopaminergic neurons and asked how inactivation of transport proteins affected iron homeostasis in vivo in mice. Loss of the cellular...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Matak, Pavle, Matak, Andrija, Moustafa, Sarah, Aryal, Dipendra K., Benner, Eric J., Wetsel, William, Andrews, Nancy C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2016
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822577/
https://ncbi.nlm.nih.gov/pubmed/26929359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519473113
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