p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs

Large parts of mammalian genomes are transcriptionally inactive and enriched with various classes of interspersed and tandem repeats. Here we show that the tumor suppressor protein p53 cooperates with DNA methylation to maintain silencing of a large portion of the mouse genome. Massive transcription...

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Detalhes bibliográficos
Main Authors: Leonova, Katerina I., Brodsky, Leonid, Lipchick, Brittany, Pal, Mahadeb, Novototskaya, Liliya, Chenchik, Alex A., Sen, Ganes C., Komarova, Elena A., Gudkov, Andrei V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538199/
https://ncbi.nlm.nih.gov/pubmed/23236145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216922110
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