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Structural basis of DNA Ligase IV-Artemis interaction in Non-Homologous End Joining (NHEJ)
DNA ligase IV (LigIV) and Artemis are central components of the Non-Homologous End Joining (NHEJ) machinery that is required for V(D)J recombination and the maintenance of genomic integrity in mammalian cells. We report here crystal structures of the LigIV DNA binding domain (DBD) in both its apo fo...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3538150/ https://ncbi.nlm.nih.gov/pubmed/23219551 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.11.004 |
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