HYPERFORIN MODULATES DENDRITIC SPINE MORPHOLOGY IN HIPPOCAMPAL PYRAMIDAL NEURONS BY ACTIVATING Ca(2+)-PERMEABLE TRPC6 CHANNELS

The standardized extract of the St. John’s wort plant (Hypericum perforatum) is commonly used to treat mild to moderate depression. Its active constituent is hyperforin, a phloroglucinol derivative that reduces the reuptake of serotonin and norepinephrine by increasing intracellular Na(+) concentrat...

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Detalhes bibliográficos
Main Authors: Leuner, Kristina, Li, Wei, Amaral, Michelle D., Rudolph, Stephanie, Calfa, Gaston, Schuwald, Anita M., Harteneck, Christian, Inoue, Takafumi, Pozzo-Miller, Lucas
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538039/
https://ncbi.nlm.nih.gov/pubmed/22815087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hipo.22052
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