Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

Kinases are dysregulated in most cancer but the frequency of specific kinase mutations is low, indicating a complex etiology in kinase dysregulation. Here we report a strategy to rapidly identify functionally important kinase targets, irrespective of the etiology of kinase pathway dysregulation, ult...

Full description

Saved in:
Bibliographic Details
Main Authors: Tyner, Jeffrey W., Yang, Wayne F., Bankhead, Armand, Fan, Guang, Fletcher, Luke B., Bryant, Jade, Glover, Jason M., Chang, Bill H., Spurgeon, Stephen E., Fleming, William H., Kovacsovics, Tibor, Gotlib, Jason R., Oh, Stephen T., Deininger, Michael W., Zwaan, C. Michel, Den Boer, Monique L., van den Heuvel-Eibrink, Marry M., O’Hare, Thomas, Druker, Brian J., Loriaux, Marc M.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537897/
https://ncbi.nlm.nih.gov/pubmed/23087056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1906
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items