Kinase Pathway Dependence in Primary Human Leukemias Determined by Rapid Inhibitor Screening

Kinases are dysregulated in most cancer but the frequency of specific kinase mutations is low, indicating a complex etiology in kinase dysregulation. Here we report a strategy to rapidly identify functionally important kinase targets, irrespective of the etiology of kinase pathway dysregulation, ult...

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Detalhes bibliográficos
Main Authors: Tyner, Jeffrey W., Yang, Wayne F., Bankhead, Armand, Fan, Guang, Fletcher, Luke B., Bryant, Jade, Glover, Jason M., Chang, Bill H., Spurgeon, Stephen E., Fleming, William H., Kovacsovics, Tibor, Gotlib, Jason R., Oh, Stephen T., Deininger, Michael W., Zwaan, C. Michel, Den Boer, Monique L., van den Heuvel-Eibrink, Marry M., O’Hare, Thomas, Druker, Brian J., Loriaux, Marc M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537897/
https://ncbi.nlm.nih.gov/pubmed/23087056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1906
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