Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolism

In Chuvash polycythemia, a homozygous 598C>T mutation in the von Hippel-Lindau gene (VHL) leads to an R200W substitution in VHL protein, impaired degradation of α-subunits of hypoxia inducible factor (HIF)-1 and HIF-2, and augmented hypoxic responses during normoxia. Chronic hypoxia of high altit...

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Main Authors: McClain, Donald A., Abuelgasim, Khadega A., Nouraie, Mehdi, Salomon-Andonie, Juan, Niu, Xiaomei, Miasnikova, Galina, Polyakova, Lydia A., Sergueeva, Adelina, Okhotin, Daniel J., Cherqaoui, Rabia, Okhotin, David, Cox, James E., Swierczek, Sabina, Song, Jihyun, Simon, M.Celeste, Huang, Jingyu, Simcox, Judith A., Yoon, Donghoon, Prchal, Josef T., Gordeuk, Victor R.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537876/
https://ncbi.nlm.nih.gov/pubmed/23015148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-012-0961-5
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