Cholesterol Is Required for Endocytosis and Endosomal Escape of Adenovirus Type 2

The species C adenovirus type 2 (Ad2) and Ad5 bind the coxsackievirus B Ad receptor and αv integrin coreceptors and enter epithelial cells by clathrin-mediated endocytosis. This pathway is rapid and efficient. It leads to cell activation and the cholesterol-dependent formation of macropinosomes. Mac...

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Bibliographic Details
Main Authors: Imelli, Nicola, Meier, Oliver, Boucke, Karin, Hemmi, Silvio, Greber, Urs F.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC353764/
https://ncbi.nlm.nih.gov/pubmed/14990728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.6.3089-3098.2004
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