In Vivo Evolution of X4 Human Immunodeficiency Virus Type 1 Variants in the Natural Course of Infection Coincides with Decreasing Sensitivity to CXCR4 Antagonists

CXCR4-using (X4) human immunodeficiency virus type 1 (HIV-1) variants evolve from CCR5-restricted (R5) HIV-1 variants. Early after their first appearance in vivo, X4 HIV-1 variants additionally use CCR5. The ability to use CCR5 in addition to CXCR4 is generally lost late in infection. Here we studie...

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Main Authors: Stalmeijer, Evelien H. B., van Rij, Ronald P., Boeser-Nunnink, Brigitte, Visser, Janny A., Naarding, Marloes A., Schols, Dominique, Schuitemaker, Hanneke
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC353738/
https://ncbi.nlm.nih.gov/pubmed/14990692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.6.2722-2728.2004
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