Cytopathic Effects of Non-Syncytium-Inducing and Syncytium-Inducing Human Immunodeficiency Virus Type 1 Variants on Different CD4(+)-T-Cell Subsets Are Determined Only by Coreceptor Expression

In peripheral blood mononuclear cells, syncytium-inducing (SI) human immunodeficiency virus type 1 (HIV-1) infected and depleted all CD4(+) T cells, including naive T cells. Non-SI HIV-1 infected and depleted only the CCR5-expressing T-cell subset. This may explain the accelerated CD4 cell loss afte...

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Bibliographic Details
Main Authors: Kwa, David, Vingerhoed, Jose, Boeser-Nunnink, Brigitte, Broersen, Silvia, Schuitemaker, Hanneke
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC114619/
https://ncbi.nlm.nih.gov/pubmed/11581413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.21.10455-10459.2001
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