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The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans

Aberrations in the p53 tumor suppressor pathway are associated with hematologic malignancies. p53-dependent cell cycle control, senescence, and apoptosis functions are actively involved in maintaining hematopoietic homeostasis under normal and stress conditions. Whereas loss of p53 function promotes...

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Détails bibliographiques
Auteurs principaux: Pant, Vinod, Quintás-Cardama, Alfonso, Lozano, Guillermina
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537308/
https://ncbi.nlm.nih.gov/pubmed/23018641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-05-356014
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