Tumor Necrosis Factor-alpha Potentiates the Cytotoxicity of Amiodarone in Hepa1c1c7 Cells: Roles of Caspase Activation and Oxidative Stress

Amiodarone (AMD), a class III antiarrhythmic drug, causes idiosyncratic hepatotoxicity in human patients. We demonstrated previously that tumor necrosis factor-alpha (TNF-α) plays an important role in a rat model of AMD-induced hepatotoxicity under inflammatory stress. In this study, we developed a...

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Detaylı Bibliyografya
Asıl Yazarlar: Lu, Jingtao, Miyakawa, Kazuhisa, Roth, Robert A., Ganey, Patricia E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537133/
https://ncbi.nlm.nih.gov/pubmed/23042730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs289
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