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Assembly of Subtype 1 Influenza Neuraminidase Is Driven by Both the Transmembrane and Head Domains

Neuraminidase (NA) is one of the two major influenza surface antigens and the main influenza drug target. Although NA has been well characterized and thought to function as a tetramer, the role of the transmembrane domain (TMD) in promoting proper NA assembly has not been systematically studied. Her...

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Detalhes bibliográficos
Main Authors: da Silva, Diogo V., Nordholm, Johan, Madjo, Ursula, Pfeiffer, Annika, Daniels, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537063/
https://ncbi.nlm.nih.gov/pubmed/23150659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.424150
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