A Combined Laser Microdissection and Mass Spectrometry Approach Reveals New Disease Relevant Proteins Accumulating in Aggregates of Filaminopathy Patients

Filaminopathy is a subtype of myofibrillar myopathy caused by mutations in FLNC, the gene encoding filamin C, and histologically characterized by pathologic accumulation of several proteins within skeletal muscle fibers. With the aim to get new insights in aggregate composition, we collected aggrega...

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Autori principali: Kley, Rudolf A., Maerkens, Alexandra, Leber, Yvonne, Theis, Verena, Schreiner, Anja, van der Ven, Peter F. M., Uszkoreit, Julian, Stephan, Christian, Eulitz, Stefan, Euler, Nicole, Kirschner, Janbernd, Müller, Klaus, Meyer, Helmut E., Tegenthoff, Martin, Fürst, Dieter O., Vorgerd, Matthias, Müller, Thorsten, Marcus, Katrin
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536902/
https://ncbi.nlm.nih.gov/pubmed/23115302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M112.023176
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