Recombinant HIV Envelope Proteins Fail to Engage Germline Versions of Anti-CD4bs bNAbs

Vaccine candidates for HIV-1 so far have not been able to elicit broadly neutralizing antibodies (bNAbs) although they express the epitopes recognized by bNAbs to the HIV envelope glycoprotein (Env). To understand whether and how Env immunogens interact with the predicted germline versions of known...

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Detalhes bibliográficos
Main Authors: Hoot, Sam, McGuire, Andrew T., Cohen, Kristen W., Strong, Roland K., Hangartner, Lars, Klein, Florian, Diskin, Ron, Scheid, Johannes F., Sather, D. Noah, Burton, Dennis R., Stamatatos, Leonidas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536657/
https://ncbi.nlm.nih.gov/pubmed/23300456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003106
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