Activated protein C ameliorates Bacillus anthracis lethal toxin-induced lethal pathogenesis in rats

BACKGROUND: Lethal toxin (LT) is a major virulence factor of Bacillus anthracis. Sprague Dawley rats manifest pronounced lung edema and shock after LT treatments, resulting in high mortality. The heart failure that is induced by LT has been suggested to be a principal mechanism of lung edema and mor...

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Autors principals: Kau, Jyh-Hwa, Shih, Yung-Luen, Lien, Te-Sheng, Lee, Chin-Cheng, Huang, Hsin-Hsien, Lin, Hung-Chi, Sun, Der-Shan, Chang, Hsin-Hou
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536616/
https://ncbi.nlm.nih.gov/pubmed/23170801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-19-98
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