Activated protein C ameliorates Bacillus anthracis lethal toxin-induced lethal pathogenesis in rats

BACKGROUND: Lethal toxin (LT) is a major virulence factor of Bacillus anthracis. Sprague Dawley rats manifest pronounced lung edema and shock after LT treatments, resulting in high mortality. The heart failure that is induced by LT has been suggested to be a principal mechanism of lung edema and mor...

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Detalhes bibliográficos
Main Authors: Kau, Jyh-Hwa, Shih, Yung-Luen, Lien, Te-Sheng, Lee, Chin-Cheng, Huang, Hsin-Hsien, Lin, Hung-Chi, Sun, Der-Shan, Chang, Hsin-Hou
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536616/
https://ncbi.nlm.nih.gov/pubmed/23170801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-19-98
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