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Ablation of cardiac myosin–binding protein-C accelerates contractile kinetics in engineered cardiac tissue

Hypertrophic cardiomyopathy (HCM) caused by mutations in cardiac myosin–binding protein-C (cMyBP-C) is a heterogenous disease in which the phenotypic presentation is influenced by genetic, environmental, and developmental factors. Though mouse models have been used extensively to study the contracti...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: de Lange, Willem J., Grimes, Adrian C., Hegge, Laura F., Ralphe, J. Carter
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536521/
https://ncbi.nlm.nih.gov/pubmed/23277475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201210837
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