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The HCM-linked W792R mutation in cardiac myosin-binding protein C reduces C6 FnIII domain stability
Cardiac myosin-binding protein C (cMyBP-C) is a functional sarcomeric protein that regulates contractility in response to contractile demand, and many mutations in cMyBP-C lead to hypertrophic cardiomyopathy (HCM). To gain insight into the effects of disease-causing cMyBP-C missense mutations on con...
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| Publicado no: | Am J Physiol Heart Circ Physiol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6032085/ https://ncbi.nlm.nih.gov/pubmed/29451820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00686.2017 |
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