Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter

The dopamine transporter (DAT) regulates the temporal and spatial actions of dopamine by reuptaking this neurotransmitter into the presynaptic neurons. We recently generated transgenic mice overexpressing DAT (DAT-tg) that have a 3-fold increase in DAT protein levels which results in a 40% reduction...

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Main Authors: Ghisi, Valentina, Ramsey, Amy J, Masri, Bernard, Gainetdinov, Raul R, Caron, Marc G, Salahpour, Ali
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536494/
https://ncbi.nlm.nih.gov/pubmed/18929645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2008.09.011
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