Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter

The dopamine transporter (DAT) regulates the temporal and spatial actions of dopamine by reuptaking this neurotransmitter into the presynaptic neurons. We recently generated transgenic mice overexpressing DAT (DAT-tg) that have a 3-fold increase in DAT protein levels which results in a 40% reduction...

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Autores principales: Ghisi, Valentina, Ramsey, Amy J, Masri, Bernard, Gainetdinov, Raul R, Caron, Marc G, Salahpour, Ali
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536494/
https://ncbi.nlm.nih.gov/pubmed/18929645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2008.09.011
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