Human Anti-Varicella-Zoster Virus (VZV) Recombinant Monoclonal Antibody Produced after Zostavax Immunization Recognizes the gH/gL Complex and Neutralizes VZV Infection

Varicella-zoster virus (VZV) is a ubiquitous, highly cell-associated, and exclusively human neurotropic alphaherpesvirus. VZV infection is initiated by membrane fusion, an event dependent in part on VZV glycoproteins gH and gL. Consistent with its location on the virus envelope, the gH/gL complex is...

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Detalhes bibliográficos
Main Authors: Birlea, Marius, Owens, Gregory P., Eshleman, Emily M., Ritchie, Alanna, Traktinskiy, Igor, Bos, Nathan, Seitz, Scott, Azarkh, Yevgeniy, Mahalingam, Ravi, Gilden, Don, Cohrs, Randall J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536365/
https://ncbi.nlm.nih.gov/pubmed/23077312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02561-12
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