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Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods

Reconstructed microbial metabolic networks facilitate a mechanistic description of the genotype-phenotype relationship through the deployment of methods in constraint-based reconstruction and analysis (COBRA). Since reconstructed networks leverage genomic data for insight and phenotype prediction, t...

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Detalles Bibliográficos
Main Authors: Lewis, Nathan E., Nagarajan, Harish, Palsson, Bernhard O.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3536058/
https://ncbi.nlm.nih.gov/pubmed/22367118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrmicro2737
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