Pharmacodynamics of a Simulated Single 1,200-Milligram Dose of Oritavancin in an In Vitro Pharmacokinetic/Pharmacodynamic Model of Methicillin-Resistant Staphylococcus aureus Infection

The safety and efficacy of a single 1,200-mg dose of the lipoglycopeptide oritavancin are currently being investigated in two global phase 3 studies of acute bacterial skin and skin structure infections. In this study, an in vitro pharmacokinetic/pharmacodynamic model was established to compare the...

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Bibliographic Details
Main Authors: Belley, Adam, Arhin, Francis F., Sarmiento, Ingrid, Deng, Hong, Rose, Warren, Moeck, Greg
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2013
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535985/
https://ncbi.nlm.nih.gov/pubmed/23089749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01428-12
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