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The Therapeutic Effect of Tigecycline, Unlike That of Ceftazidime, Is Not Influenced by whether the Klebsiella pneumoniae Strain Produces Extended-Spectrum β-Lactamases in Experimental Pneumonia in Rats

The efficacies of tigecycline and ceftazidime against fatal pneumonia in rats caused by an extended-spectrum β-lactamase (ESBL)-positive Klebsiella pneumoniae strain or its wild-type (WT) progenitor were compared. Ceftazidime at 12.5 or 50 mg/kg of body weight twice daily (b.i.d.) was effective (50%...

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書誌詳細
主要な著者: Goessens, Wil H. F., Mouton, Johan W., ten Kate, Marian T., Sörgel, Fritz, Kinzig, Martina, Bakker-Woudenberg, Irma A. J. M.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535950/
https://ncbi.nlm.nih.gov/pubmed/23129049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01154-12
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