Population Pharmacokinetics of Fusidic Acid: Rationale for Front-Loaded Dosing Regimens Due to Autoinhibition of Clearance

The objectives of this analysis were to develop a population pharmacokinetic (PK) model to describe the absorption and disposition of fusidic acid after single and multiple doses and to determine the effect of food on the rate and extent of bioavailability. Plasma PK data from three phase 1 studies...

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Hlavní autoři: Bulitta, Jürgen B., Okusanya, Olanrewaju O., Forrest, Alan, Bhavnani, Sujata M., Clark, Kay, Still, J. Gordon, Fernandes, Prabhavathi, Ambrose, Paul G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2013
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535918/
https://ncbi.nlm.nih.gov/pubmed/23147726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01354-12
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