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DNA methylation of the filaggrin gene adds to the risk of eczema associated with loss-of-function variants
BACKGROUND: Loss-of-function variants within the filaggrin gene (FLG) are associated with a dysfunctional skin barrier that contributes to the development of eczema. Epigenetic modifications, such as DNA methylation, are genetic regulatory mechanisms that modulate gene expression without changing th...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535679/ https://ncbi.nlm.nih.gov/pubmed/23003573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jdv.12000 |
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