Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins

129/SvEv mice with a loss-of-function mutation in the heterotrimeric G protein α-subunit gene Gnai3 have fusions of ribs and lumbar vertebrae, indicating a requirement for Gα(i) (the “inhibitory” class of α-subunits) in somite derivatives. Mice with mutations of Gnai1 or Gnai2 have neither defect, b...

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Bibliographic Details
Main Authors: Plummer, Nicholas W., Spicher, Karsten, Malphurs, Jason, Akiyama, Haruhiko, Abramowitz, Joel, Nürnberg, Bernd, Birnbaumer, Lutz
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2012
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535641/
https://ncbi.nlm.nih.gov/pubmed/23236180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219810110
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