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Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins
129/SvEv mice with a loss-of-function mutation in the heterotrimeric G protein α-subunit gene Gnai3 have fusions of ribs and lumbar vertebrae, indicating a requirement for Gα(i) (the “inhibitory” class of α-subunits) in somite derivatives. Mice with mutations of Gnai1 or Gnai2 have neither defect, b...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535641/ https://ncbi.nlm.nih.gov/pubmed/23236180 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219810110 |
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