Disruption of the p53-Mdm2 Complex by Nutlin-3 Reveals Different Cancer Cell Phenotypes

INTRODUCTION: Mdm2 inhibits p53 transactivation by forming a p53-Mdm2 complex on chromatin. Upon DNA damage-induced complex disruption, such latent p53 can be activated, but in cells overexpressing Mdm2 because of a homozygous single nucleotide polymorphism at position 309 (T→G) of mdm2, the complex...

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Main Authors: Arva, Nicoleta C., Talbott, Kathryn E., Okoro, Danielle R., Brekman, Angelika, Qiu, Wei Gang, Bargonetti, Jill
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535287/
https://ncbi.nlm.nih.gov/pubmed/18646312
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