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Mitomycin–DNA Adducts Induce p53-Dependent and p53-Independent Cell Death Pathways
10-Decarbamoyl-mitomycin C (DMC), a mitomycin C (MC) derivative, generates an array of DNA monoadducts and interstrand cross-links stereoisomeric to those that are generated by MC. DMC was previously shown in our laboratory to exceed the cytotoxicity of MC in a human leukemia cell line that lacks a...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2886584/ https://ncbi.nlm.nih.gov/pubmed/17530733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb700060t |
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