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Regioselective Formation of Acrolein-derived Cyclic 1,N(2)-Propanodeoxyguanosine Adducts Mediated by Amino Acids, Proteins, and Cell Lysates
Acrolein (Acr) is a major component in cigarette smoke and a ubiquitous environmental pollutant. It is also formed as a product of lipid peroxidation. Following ring closure via the Michael addition, Acr modifies deoxyguanosine (dG) in DNA by forming cyclic 1,N(2)-propanodeoxyguanosine adducts (OHPd...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535281/ https://ncbi.nlm.nih.gov/pubmed/22853434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx3002252 |
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