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Structure-based Methods for Predicting Target Mutation-induced Drug Resistance and Rational Drug Design to Overcome the Problem
Drug resistance has become one of the biggest challenges in drug discovery/development and attracted great research interests worldwide. During the last decade, computational strategies have been developed to predict target mutation-induced drug resistance. Meanwhile, various molecular design strate...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535271/ https://ncbi.nlm.nih.gov/pubmed/22789991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2012.06.018 |
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