Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target

Protein kinases are central targets for drug-based cancer treatment. To avoid functional impairment, the cell develops mechanisms of drug resistance, primarily based on adaptive mutations. Redesigning a drug to target a drug-resistant mutant kinase constitutes a therapeutic challenge. We approach th...

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Hlavní autoři: Fernández, Ariel, Sanguino, Angela, Peng, Zhenghong, Crespo, Alejandro, Ozturk, Eylem, Zhang, Xi, Wang, Shimei, Bornmann, William, Lopez-Berestein, Gabriel
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2769247/
https://ncbi.nlm.nih.gov/pubmed/17483313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-0345
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