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Role of Trp19 and Tyr200 in Catalysis by the γ-Class Carbonic Anhydrase from Methanosarcina thermophila

Although widely distributed in Nature, only two γ class carbonic anhydrases are reported besides the founding member (Cam). Although roles for active-site residues important for catalysis have been identified in Cam, second shell residues have not been investigated. Two residues (Trp19 and Tyr200),...

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Bibliographic Details
Main Authors: Zimmerman, Sabrina, Domsic, John F., Tu, Chingkuang, Robbins, Arthur H., McKenna, Robert, Silverman, David N., Ferry, James G.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534908/
https://ncbi.nlm.nih.gov/pubmed/23111186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2012.10.010
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