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Flippase-Mediated Phospholipid Asymmetry Promotes Fast Cdc42 Recycling in Dynamic Maintenance of Cell Polarity
Lipid asymmetry at the plasma membrane is essential for such processes as cell polarity, cytokinesis and phagocytosis(1-3). Here we identify the lipid flippase complex, composed of Lem3, Dnf1 or Dnf2(4), to play a role in the dynamic recycling of the Cdc42 GTPase, a key regulator of cell polarity(5)...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3534761/ https://ncbi.nlm.nih.gov/pubmed/22344035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2444 |
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