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Effects of protein interaction data integration, representation and reliability on the use of network properties for drug target prediction

BACKGROUND: Previous studies have noted that drug targets appear to be associated with higher-degree or higher-centrality proteins in interaction networks. These studies explicitly or tacitly make choices of different source databases, data integration strategies, representation of proteins and comp...

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Detalhes bibliográficos
Main Authors: Mora, Antonio, Donaldson, Ian M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534413/
https://ncbi.nlm.nih.gov/pubmed/23146171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-13-294
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