Electroporation-mediated gene delivery of cleavage-resistant pro–nerve growth factor causes retinal neuro- and vascular degeneration

PURPOSE: Neurotrophins, including nerve growth factor (NGF), are secreted by glia as a pro-form (proNGF) that is normally cleaved into the mature ligand. Increases of proNGF has been well documented in retinal neurodegenerative diseases. Since systemic overexpression of proNGF exhibits embryonic let...

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Autors principals: Matragoon, Suraporn, Al-Gayyar, Mohammed M.H., Mysona, Barbara A., Abdelsaid, Mohammed A., Pillai, Bindu A., Neet, Kenneth E., Fagan, Susan C., El-Remessy, Azza B.
Format: Artigo
Idioma:Inglês
Publicat: Molecular Vision 2012
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534146/
https://ncbi.nlm.nih.gov/pubmed/23288991
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